Beneficial Effects of Sambucus nigra in Chronic Stress-Induced Neurobehavioral and Biochemical Perturbation in Rodents

Background: Stress is the causative factor for various diseases and disorders faced by majority of diseased population. The leaves Sambucus nigra (S. nigra) are attributed to neuropharmacological properties as per literature. Considering above, S. hydroalcoholic extract was tested adaptogenic activity in animals. Objective: study deals with evaluation using cold immobilization footshock induced stress. Materials Methods: (200 400 mg/kg) administered treatment groups 1 hour before 14 consecutive days stress 10 days, respectively. current work carrying out investigate against perturbations behaviour (sexual behaviour, depression, cognitive dysfunction). Suppressed male sexual percentage active avoidance response duration immobility were used indices. Additionally, liver function (SGOT, SGPT, ALP), lipid profiles (TC, TG, HDL, LDL, VLDL) differential leukocytes counts (neutrophils, eosinophils, lymphocyte, monocyte) assessed terms Diazepam (1 served standard agent literature review comparison. Results: All these chronic stress-induced reversed, dose-dependently (2000 diazepam mg/kg). dose group mg/kg p.o. method showed significant variation (P< 0.1) when compared control group. Conclusion: indicated qualitatively results comparable diazepam, a range biochemical behavioural